鼠曲草黄酮调节脂代谢活性研究.doc

摘要:目的：研究鼠曲草黄酮对糖尿病小鼠血脂代谢紊乱的改善作用。方法：首先采用腹腔注射链脲佐菌素( STZ )的方法构建小鼠的糖尿病模型，并以盐酸二甲双胍为对照，观察连续灌胃21d不同剂量的鼠曲草黄酮对糖尿病小鼠体重、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）的含量和动脉硬化指数（AI）的影响。结果：鼠曲草黄酮可以明显改善糖尿病小鼠的血脂代谢紊乱情况，显著地降低糖尿病小鼠体内的TG、TC、LDL-C和AI、升高糖尿病小鼠的HDL-C，其中低剂量的鼠曲草黄酮灌胃（100 mg/kg.d）调节血脂代谢效果与盐酸二甲双胍相当。结论：鼠曲草总黄酮具有有效地调节糖尿病小鼠血脂代谢紊乱的活性。  

关键词  鼠曲草黄酮；糖尿病；降血脂

Abstract:Objective: The objective of this paper was to study the activities of Gnaphalium Affine Flavonoids on blood lipids in diabetic mice. Method: Diabetes was induced by intraperitoneal injection of streptozotocin in mice. The changes of body weight, TC, TG, HDL-C, and LDL-C, and AI of mice were examined. Results: The blood lipids of diabetic mice were significantly ameliorated by Gnaphalium Affine Flavonoids. Compared with diabetic mice group, the levels of TC, TG LDL-C and AI of Gnaphalium Affine Flavonoids group were significantly decreased, and the level of HDL-C remarkably increased. The effects of improvement induced by high dose Gnaphalium Affine Flavonoids were as same as metformin hydrochloride group. Inclusion: Gnaphalium Affine Flavonoids could effectively ameliorate the levels of blood lipids of diabetic mice.

Keywords  Gnaphalium Affine Flavonoids  Diabetes  Blood lipids